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Canine Achaete-scute homolog 1 ELISA Kit | ASH1 elisa kit

Canine Achaete-scute homolog 1 ELISA Kit

Gene Names
ASCL1; ASH1; HASH1; MASH1; bHLHa46
Reactivity
Canine
Synonyms
Achaete-scute homolog 1; Canine Achaete-scute homolog 1 ELISA Kit; ASH1 elisa kit
Ordering
For Research Use Only!
Reactivity
Canine
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Assay Type
Competitive
Detection Range
0.5-10ng/mL
Sensitivity
0.1ng/mL
Preparation and Storage
Store all reagents at 2-8 degree C.
Product Categories/Family for ASH1 elisa kit

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
429
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,454 Da
NCBI Official Full Name
achaete-scute homolog 1
NCBI Official Synonym Full Names
achaete-scute family bHLH transcription factor 1
NCBI Official Symbol
ASCL1
NCBI Official Synonym Symbols
ASH1; HASH1; MASH1; bHLHa46
NCBI Protein Information
achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46
UniProt Protein Name
Achaete-scute homolog 1
Protein Family
UniProt Gene Name
ASCL1
UniProt Synonym Gene Names
ASH1; BHLHA46; HASH1; ASH-1; hASH1; bHLHa46
UniProt Entry Name
ASCL1_HUMAN

NCBI Description

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Uniprot Description

ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: cell soma; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity

Biological Process: vestibular nucleus development; response to lithium ion; musculoskeletal movement, spinal reflex action; olfactory pit development; cell maturation; regulation of mitotic cell cycle; neuron migration; neuroblast fate determination; negative regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; response to folic acid; positive regulation of neuron apoptosis; neuron fate specification; oligodendrocyte development; positive regulation of Notch signaling pathway; central nervous system neuron development; Notch signaling pathway; response to retinoic acid; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; regulation of timing of subpallium neuron differentiation; positive regulation of cell cycle; cerebral cortex GABAergic interneuron differentiation; negative regulation of neuron differentiation; neurogenesis; regulation of gene expression; subpallium neuron fate commitment; commitment of a neuronal cell to a specific type of neuron in the forebrain; neuroblast proliferation; regulation of epithelial cell differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Central Hypoventilation Syndrome, Congenital

Research Articles on ASH1

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Product Notes

The Canine ASH1 ascl1 (Catalog #AAA753868) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA753868 ELISA Kit recognizes Canine ASH1. It is sometimes possible for the material contained within the vial of "Achaete-scute homolog 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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