Arylsulfatase G Recombinant Protein | ARSG recombinant protein

Recombinant Human Arylsulfatase G

Cat. Num. AAA1394876

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Arylsulfatase G; Recombinant Human Arylsulfatase G; ARSG recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 17-525aa; Full Length
• Sequence: GFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA
• Sequence Length: 525

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for ARSG recombinant protein

Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate.

Product Categories/Family for ARSG recombinant protein

Tags & Cell Markers

References

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.DNA Res. 6:63-70(1999) The secreted protein discovery initiative (SPDI) , a large-scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment.Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.Genome Res. 13:2265-2270(2003) Molecular and biochemical characterisation of a novel sulphatase gene arylsulfatase G (ARSG) .Ferrante P., Messali S., Meroni G., Ballabio A.Eur. J. Hum. Genet. 10:813-818(2002) Arylsulfatase G, a novel lysosomal sulfatase.Frese M.A., Schulz S., Dierks T.J. Biol. Chem. 283:11388-11395(2008)

NCBI and Uniprot Product Information

• NCBI GI #: 392050740
• NCBI GeneID: 22901
• NCBI Accession #: NP_001254656.1
• NCBI GenBank Nucleotide #: NM_001267727.1
• UniProt Accession #: Q96EG1; Q6UXF2; Q9Y2K4
• Molecular Weight: 71.3 kDa
• NCBI Official Full Name: arylsulfatase G
• NCBI Official Synonym Full Names: arylsulfatase G
• NCBI Official Symbol: ARSG
• NCBI Protein Information: arylsulfatase G
• UniProt Protein Name: Arylsulfatase G
• Protein Family: Arylsulfatase
• UniProt Gene Name: ARSG
• UniProt Synonym Gene Names: KIAA1001; ASG
• UniProt Entry Name: ARSG_HUMAN

NCBI Description

The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Description

ARSG: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate. Belongs to the sulfatase family.

Protein type: Secreted; EC 3.1.6.-; Endoplasmic reticulum; Secreted, signal peptide; Hydrolase; Kinase, other

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space; lysosome

Molecular Function: arylsulfatase activity; metal ion binding

Biological Process: cellular protein metabolic process; glycosphingolipid metabolic process; post-translational protein modification; sphingolipid metabolic process; sulfur metabolic process