Human aryl hydrocarbon receptor nuclear translocator-like 2 ELISA Kit | ARNTL2 elisa kit
Human Aryl hydrocarbon receptor nuclear transloCator-like protein 2, ARNTL2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
ARNTL2: ARNTL2-CLOCK heterodimers activate E-box element (5'- CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. 8 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 12p12.2-p11.2
Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein dimerization activity; signal transducer activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; circadian rhythm; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of circadian rhythm; entrainment of circadian clock; signal transduction
Research Articles on ARNTL2
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Product Notes
The Human ARNTL2 arntl2 (Catalog #AAA9324227) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324227 ELISA Kit recognizes Human ARNTL2. It is sometimes possible for the material contained within the vial of "aryl hydrocarbon receptor nuclear translocator-like 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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