Rho guanine nucleotide exchange factor 2 (ARHGEF2) Recombinant Protein | ARHGEF2 recombinant protein

Recombinant Dog Rho guanine nucleotide exchange factor 2 (ARHGEF2), partial

• Gene Names: ARHGEF2; GEF-H1; GEF-H1/LFC
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Rho guanine nucleotide exchange factor 2 (ARHGEF2); Recombinant Dog Rho guanine nucleotide exchange factor 2 (ARHGEF2); partial; ARHGEF2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 986

• Species: Canis familiaris (Dog) (Canis lupus familiaris)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ARHGEF2 recombinant protein

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 50950229
• NCBI GeneID: 403498
• NCBI Accession #: NP_001002995.1
• NCBI GenBank Nucleotide #: NM_001002995.1
• UniProt Accession #: Q865S3; Q865S2
• Molecular Weight: 108,959 Da
• NCBI Official Full Name: rho guanine nucleotide exchange factor 2 isoform A
• NCBI Official Synonym Full Names: Rho/Rac guanine nucleotide exchange factor 2
• NCBI Official Symbol: ARHGEF2
• NCBI Official Synonym Symbols: GEF-H1; GEF-H1/LFC
• NCBI Protein Information: rho guanine nucleotide exchange factor 2
• UniProt Protein Name: Rho guanine nucleotide exchange factor 2
• Protein Family: Rho guanine nucleotide exchange factor
• UniProt Gene Name: ARHGEF2
• UniProt Synonym Gene Names: GEF-H1

Uniprot Description

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons (). Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (PubMed:12604587).