Mouse adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 ELISA Kit | APPL1 elisa kit
Mouse DCC-interacting protein 13-alpha, APPL1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
APPL: an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage.
Protein type: Nuclear receptor co-regulator; Adaptor/scaffold
Cellular Component: membrane; endosome membrane; NuRD complex; vesicle membrane; cytosol; nucleus; endosome
Molecular Function: protein kinase B binding; identical protein binding
Biological Process: cell proliferation; regulation of glucose import; cell cycle
Research Articles on APPL1
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Product Notes
The Mouse APPL1 appl1 (Catalog #AAA9319841) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319841 ELISA Kit recognizes Mouse APPL1. It is sometimes possible for the material contained within the vial of "adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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