APCS recombinant protein

Recombinant Human APCS protein

Cat. Num. AAA1562744

• Gene Names: APCS; SAP; PTX2
• Purity: >90% as determined by SDS-PAGE
• Synonyms: APCS; Recombinant Human APCS protein; Serum amyloid P-component; SAP; 9.5S alpha-1-glycoprotein; APCS recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human APCS (Leu23-Val223) was fused with GST tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for APCS recombinant protein

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Product Categories/Family for APCS recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4502133
• NCBI GeneID: 325
• NCBI Accession #: NP_001630.1
• NCBI GenBank Nucleotide #: NM_001639.3
• UniProt Accession #: P02743
• Molecular Weight: 25,387 Da
• NCBI Official Full Name: serum amyloid P-component
• NCBI Official Synonym Full Names: amyloid P component, serum
• NCBI Official Symbol: APCS
• NCBI Official Synonym Symbols: SAP; PTX2
• NCBI Protein Information: serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein
• UniProt Protein Name: Serum amyloid P-component
• UniProt Gene Name: APCS
• UniProt Synonym Gene Names: PTX2; SAP
• UniProt Entry Name: SAMP_HUMAN

NCBI Description

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Uniprot Description

APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.

Protein type: Secreted, signal peptide; Secreted; Chaperone

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function: complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; acute-phase response; negative regulation of acute inflammatory response; innate immune response; chaperone-mediated protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction