Human adaptor-related protein complex 2, alpha 2 subunit ELISA Kit | AP2A2 elisa kit
Human AP-2 complex subunit alpha-2, AP2A2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
AP2A2: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. Belongs to the adaptor complexes large subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasmic membrane-bound vesicle; plasma membrane; AP-2 adaptor complex; cytosol
Molecular Function: protein binding; lipid binding; protein kinase binding; protein transporter activity
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; intracellular protein transport; synaptic transmission; nerve growth factor receptor signaling pathway; viral reproduction; ephrin receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of defense response to virus by virus
Research Articles on AP2A2
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Product Notes
The Human AP2A2 ap2a2 (Catalog #AAA9336545) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336545 ELISA Kit recognizes Human AP2A2. It is sometimes possible for the material contained within the vial of "adaptor-related protein complex 2, alpha 2 subunit, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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