UBASH3A Antibody | anti-UBASH3A antibody

UBASH3A Antibody

Cat. Num. AAA8502507

• Gene Names: UBASH3A; TULA; CLIP4; STS-2; TULA-1
• Synonyms: UBASH3A; UBASH3A Antibody; anti-UBASH3A antibody

• Sequence Length: 623

NCBI and Uniprot Product Information

• NCBI GI #: 49640014
• NCBI GeneID: 53347
• NCBI Accession #: NP_001001895.1
• NCBI GenBank Nucleotide #: NM_001001895.2
• UniProt Accession #: P57075; Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9; G5E9E4
• Molecular Weight: 59,167 Da
• NCBI Official Full Name: ubiquitin-associated and SH3 domain-containing protein A isoform 2
• NCBI Official Synonym Full Names: ubiquitin associated and SH3 domain containing A
• NCBI Official Symbol: UBASH3A
• NCBI Official Synonym Symbols: TULA; CLIP4; STS-2; TULA-1
• NCBI Protein Information: ubiquitin-associated and SH3 domain-containing protein A
• UniProt Protein Name: Ubiquitin-associated and SH3 domain-containing protein A
• Protein Family: Ubiquitin-associated and SH3 domain-containing protein
• UniProt Gene Name: UBASH3A
• UniProt Synonym Gene Names: STS2; CLIP4; STS-2; TULA-1

NCBI Description

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.