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Western Blot (WB) (Western blot analysis LAT using Jurkat whole cell lysates)

LAT Antibody | anti-LAT antibody

LAT Antibody

Gene Names
LAT; LAT1; pp36; IMD52
Synonyms
LAT; LAT Antibody; anti-LAT antibody
Ordering
For Research Use Only!
Sequence Length
233

Western Blot (WB)

(Western blot analysis LAT using Jurkat whole cell lysates)

Western Blot (WB) (Western blot analysis LAT using Jurkat whole cell lysates)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,774 Da
NCBI Official Full Name
linker for activation of T-cells family member 1 isoform b
NCBI Official Synonym Full Names
linker for activation of T cells
NCBI Official Symbol
LAT
NCBI Official Synonym Symbols
LAT1; pp36; IMD52
NCBI Protein Information
linker for activation of T-cells family member 1
UniProt Protein Name
Linker for activation of T-cells family member 1
Protein Family
UniProt Gene Name
LAT
UniProt Synonym Gene Names
pp36

NCBI Description

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Research Articles on LAT

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Product Notes

The LAT lat (Catalog #AAA8517022) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LAT, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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