HABP2 Antibody | anti-HABP2 antibody

HABP2 Antibody

Cat. Num. AAA8513122

• Gene Names: HABP2; FSAP; HABP; PHBP; HGFAL; NMTC5
• Synonyms: HABP2; HABP2 Antibody; anti-HABP2 antibody

• Sequence Length: 534

Western Blot (WB)

(Western blot analysis HABP2 using HeLa whole cell lysates)

NCBI and Uniprot Product Information

• NCBI GI #: 295054188
• NCBI GeneID: 3026
• NCBI Accession #: NP_001171131.1
• NCBI GenBank Nucleotide #: NM_001177660.2
• UniProt Accession #: Q14520; O00663; A8K467; B7Z8U5; F5H5M6
• Molecular Weight: 59,864 Da
• NCBI Official Full Name: hyaluronan-binding protein 2 isoform 2
• NCBI Official Synonym Full Names: hyaluronan binding protein 2
• NCBI Official Symbol: HABP2
• NCBI Official Synonym Symbols: FSAP; HABP; PHBP; HGFAL; NMTC5
• NCBI Protein Information: hyaluronan-binding protein 2
• UniProt Protein Name: Hyaluronan-binding protein 2
• Protein Family: Hyaluronan-binding protein
• UniProt Gene Name: HABP2
• UniProt Synonym Gene Names: HGFAL; PHBP; FSAP

NCBI Description

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).