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Western Blot (WB)
(Western Blot analysis of COS7 cells with Phospho-Gab 1 (Tyr627) Polyclonal Antibody)
Met Signaling Antibody Kit | Met antibody kit
Met Signaling Antibody Sampler Kit
Applications
Western Blot
Synonyms
Met Signaling; Met Signaling Antibody Sampler Kit; Met antibody kit
Applicable Applications for Met antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of COS7 cells with Phospho-Gab 1 (Tyr627) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of COS7 cells with Phospho-Gab 1 (Tyr627) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with Phospho-Gab 1 (Tyr659) Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with Phospho-Gab 1 (Tyr659) Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of HepG2 cells using Met Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of HepG2 cells using Met Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of HuvEc cells with Phospho-Met (Tyr1234) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of HuvEc cells with Phospho-Met (Tyr1234) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of 293 cells with Phospho-Met (Tyr1349) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of 293 cells with Phospho-Met (Tyr1349) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with Phospho-Met (Tyr1356) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with Phospho-Met (Tyr1356) Polyclonal Antibody)
Related Product Information for Met antibody kit
Background: Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor (HGF, also known as scatter factor), is a disulfide-linked heterodimer made of 45 kDa alpha- and 145 kDa beta-subunits. The alpha-subunit and the amino- terminal region of the beta-subunit form the extracellular domain. The remainder of the beta-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of Met with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. These fundamental events are important for all of the biological functions involving Met kinase activity. Addition of a phosphate at cytoplasmic Tyr1003 is essential for ubiquitination and Met protein degradation. Phosphorylation of Tyr1234/1235 in the Met kinase domain is critical to kinase activation. Phosphorylation of Tyr1349 in the Met cytoplasmic domain provides a direct binding site for Gab1. Altered Met levels and/or tyrosine kinase activities are found in several types of tumors, including renal, colon and breast cancers. Thus, Met is an attractive cancer target.
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Product Notes
The Met (Catalog #AAA2550035) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Met Signaling can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Met for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Met Signaling, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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