Integrin Antibody Kit | ITGB1 antibody kit

Integrin Antibody Sampler Kit

Cat. Num. AAA2550055

• Applications: Western Blot
• Synonyms: Integrin; Integrin Antibody Sampler Kit; ITGB1 antibody kit

• Sequence Length: 803

• Applicable Applications for ITGB1 antibody kit: Western Blot (WB)

Western Blot (WB)

(Western Blot analysis of Hela cells with Integrin alpha5 Polyclonal Antibody.)

Western Blot (WB)

(Western Blot analysis of Hela cells using Integrin alphaV Polyclonal Antibody at dilution of 1:1000.)

Western Blot (WB)

(Western Blot analysis of K562 cells using Integrin alpha4 Polyclonal Antibody at dilution of 1:1000.)

Western Blot (WB)

(Western Blot analysis of NIH-3T3 cells using Integrin beta1 Polyclonal Antibody at dilution of 1:500.)

Western Blot (WB)

(Western Blot analysis of NIH-3T3 cells using Integrin beta3 Polyclonal Antibody at dilution of 1:500.)

Western Blot (WB)

(Western Blot analysis of Jurkat cells using Integrin beta5 Polyclonal Antibody at dilution of 1:1000.)

Related Product Information for ITGB1 antibody kit

Background: Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).

NCBI and Uniprot Product Information

• NCBI GI #: 212214
• NCBI GeneID: 374058
• Molecular Weight: 88,554 Da
• NCBI Official Full Name: integrin
• NCBI Official Synonym Full Names: integrin subunit beta 1
• NCBI Official Symbol: ITGB1
• NCBI Protein Information: integrin beta-1
• UniProt Protein Name: Integrin beta-1
• Protein Family: Integrin
• UniProt Gene Name: ITGB1

Uniprot Description

ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).

Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component: cell; cell surface; focal adhesion; integrin complex; invadopodium membrane; lamellipodium; melanosome; plasma membrane

Molecular Function: metal ion binding; protein binding; receptor activity

Biological Process: cell adhesion mediated by integrin; cell-matrix adhesion; integrin-mediated signaling pathway