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Western Blot (WB)
(Western Blot analysis of 1) KB, 2) MCF7 cells with Phospho-IRS-1 (Tyr896) Polyclonal Antibody at dilution of 1:500)
Insulin Receptor Substrate Antibody Kit | chico antibody kit
Insulin Receptor Substrate Antibody Sampler Kit
Gene Names
chico; anon-WO0078940.1; anon-WO0078940.4; BcDNA.GH11263; BcDNA:GH11263; CG5686; chic; Chico; CHICO; dIRS; DmelCG5686; fs(2)4; fs(2)ry4; IRS; IRS/chico
Applications
Western Blot
Synonyms
Insulin Receptor Substrate; Insulin Receptor Substrate Antibody Sampler Kit; chico antibody kit
Sequence Length
968
Applicable Applications for chico antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of 1) KB, 2) MCF7 cells with Phospho-IRS-1 (Tyr896) Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of 1) KB, 2) MCF7 cells with Phospho-IRS-1 (Tyr896) Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of 293T cells with Phospho-IRS-1 (Ser323) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of 293T cells with Phospho-IRS-1 (Ser323) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of VEC cells with Phospho-IRS-1 (Ser307) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of VEC cells with Phospho-IRS-1 (Ser307) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of SH-SY5Y cells with Phospho-IRS-1 (Ser636) Polyclonal Antibody at dilution of 1:2000)
Western Blot (WB)
(Western Blot analysis of SH-SY5Y cells with Phospho-IRS-1 (Ser636) Polyclonal Antibody at dilution of 1:2000)
Western Blot (WB)
(Western Blot analysis of 293T cells with Phospho-IRS-1 (Ser794) Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of 293T cells with Phospho-IRS-1 (Ser794) Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with Phospho-IRS-1 (Ser312) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with Phospho-IRS-1 (Ser312) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of 293 cells using IRS-1 Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of 293 cells using IRS-1 Polyclonal Antibody at dilution of 1:500.)
Related Product Information for chico antibody kit
Background: Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase. IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin. IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK and IKK while Ser789 is phosphorylated by SIK-2, a member of the AMPK family. The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively. Phosphorylation of IRS-1 at Ser1101 is mediated by PKCtheta and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
insulin receptor substrate
NCBI Official Symbol
chico
NCBI Official Synonym Symbols
anon-WO0078940.1; anon-WO0078940.4; BcDNA.GH11263; BcDNA:GH11263; CG5686; chic; Chico; CHICO; dIRS; DmelCG5686; fs(2)4; fs(2)ry4; IRS; IRS/chico
NCBI Protein Information
CG5686 gene product from transcript CG5686-RB
Protein Family
Research Articles on chico
Similar Products
Product Notes
The chico (Catalog #AAA2550116) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Insulin Receptor Substrate can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the chico for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Insulin Receptor Substrate, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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