Betatrophin Recombinant Protein | Gm6484 recombinant protein

Recombinant Mouse Betatrophin

Cat. Num. AAA1458629

• Gene Names: Angptl8; Rifl; Gm6484; EG624219
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Betatrophin; Recombinant Mouse Betatrophin; Betatrophin1; Gm6484 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 16-198. Full Length of Mature Protein
• Sequence: VRPAPVAPLGGPEPAQYEELTLLFHGALQLGQALNGVYRATEARLTEAGHSLGLYDRALEFLGTEVRQGQDATQELRTSLSEIQVEEDALHLRAEATARSLGEVARAQQALRDTVRRLQVQLRGAWLGQAHQEFETLKARADKQSHLLWALTGHVQRQQREMAEQQQWLRQIQQRLHTAALPA

• Production Note: Special Offer: The Baculovirus host-expressed protein is manufactured from a stock plasmid containing the protein gene. Baculovirushost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Baculovirus host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Baculovirus host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Gm6484 recombinant protein

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3.

References

Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) A mouse knockout library for secreted and transmembrane proteins.Tang T., Li L., Tang J., Li Y., Lin W.Y., Martin F., Grant D., Solloway M., Parker L., Ye W., Forrest W., Ghilardi N., Oravecz T., Platt K.A., Rice D.S., Hansen G.M., Abuin A., Eberhart D.E., Godowski P., Holt K.H., Peterson A., Zambrowicz B.P., de Sauvage F.J.Nat. Biotechnol. 28:749-755(2010) Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism.Ren G., Kim J.Y., Smas C.M.Am. J. Physiol. 303:E334-E351(2012) Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels.Zhang R.Biochem. Biophys. Res. Commun. 424:786-792(2012) Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family.Fu Z., Yao F., Abou-Samra A.B., Zhang R.Biochem. Biophys. Res. Commun. 430:1126-1131(2013) Atypical angiopoietin-like protein that regulates ANGPTL3.Quagliarini F., Wang Y., Kozlitina J., Grishin N.V., Hyde R., Boerwinkle E., Valenzuela D.M., Murphy A.J., Cohen J.C., Hobbs H.H.Proc. Natl. Acad. Sci. U.S.A. 109:19751-19756(2012) Betatrophin a hormone that controls pancreatic beta cell proliferation.Yi P., Park J.S., Melton D.A.Cell 153:747-758(2013) Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis.Wang Y., Quagliarini F., Gusarova V., Gromada J., Valenzuela D.M., Cohen J.C., Hobbs H.H.Proc. Natl. Acad. Sci. U.S.A. 110:16109-16114(2013) Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting.Jiao Y., Le Lay J., Yu M., Naji A., Kaestner K.H.Diabetes 63:1283-1288(2014) Perspectives on the activities of ANGPTL8/betatrophin.Yi P., Park J.S., Melton D.A.Cell 159:467-468(2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion.Gusarova V., Alexa C.A., Na A., Stevis P.E., Xin Y., Bonner-Weir S., Cohen J.C., Hobbs H.H., Murphy A.J., Yancopoulos G.D., Gromada J.Cell 159:691-696(2014)

NCBI and Uniprot Product Information

• NCBI GI #: 124301204
• NCBI GeneID: 624219
• NCBI Accession #: NP_001074409.1
• NCBI GenBank Nucleotide #: NM_001080940.1
• UniProt Accession #: Q8R1L8
• Molecular Weight: 22.5 kDa
• NCBI Official Full Name: angiopoietin-like protein 8
• NCBI Official Synonym Full Names: angiopoietin-like 8
• NCBI Official Symbol: Angptl8
• NCBI Official Synonym Symbols: Rifl; Gm6484; EG624219
• NCBI Protein Information: angiopoietin-like protein 8
• UniProt Protein Name: Angiopoietin-like protein 8
• UniProt Gene Name: Angptl8
• UniProt Entry Name: ANGL8_MOUSE

Uniprot Description

EG624219: Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage. In response to food intake. Interacts with ANGPTL3

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: cell maturation; cellular lipid metabolic process; fat cell differentiation; glucose metabolic process; lipid metabolic process; negative regulation of lipoprotein lipase activity; regulation of lipid metabolic process; regulation of lipoprotein metabolic process