Anaphase-promoting complex subunit 7 (Anapc7) Recombinant Protein | Anapc7 recombinant protein
Recombinant Mouse Anaphase-promoting complex subunit 7 (Anapc7)
cyclosome (APC
C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC
C and for the interaction of APC
C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
Uniprot Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains ().