RAC-gamma serine/threonine-protein kinase (Akt3) Recombinant Protein | Akt3 recombinant protein
Recombinant Rat RAC-gamma serine/threonine-protein kinase (Akt3)
threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
NCBI and Uniprot Product Information
NCBI Description
kinase that associates with both protein kinase C subspecies and beta gamma subunits of G proteins [RGD, Feb 2006]
Uniprot Description
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis ().
Research Articles on Akt3
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Product Notes
The Akt3 akt3 (Catalog #AAA1385860) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-479, full length protein. The amino acid sequence is listed below: SDVTIVKEDW VQKRGEYIKN WRPRYFLLKT DGSFIGYKEK PQDVDLPYPL NNFSVAKCQL MKTERPKPNT FIIRCLQWTT VIERTFHVDT PEEREEWTEA IQAVADRLQR QEEERMNCSP TSQIDNIGEE EMDASTTHHK RKTMNDFDYL KLLGKGTFGK VILVREKASG KYYAMKILKK EVIIAKDEVA HTLTESRVLK NTRHPFLTSL KYSFQTKDRL CFVMEYVNGG ELFFHLSRER VFSEDRTRFY GAEIVSALDY LHSGKIVYRD LKLENLMLDK DGHIKITDFG LCKEGITDAA TMKTFCGTPE YLAPEVLEDN DYGRAVDWWG LGVVMYEMMC GRLPFYNQDH EKLFELILME DIKFPRTLSS DAKSLLSGLL IKDPNKRLGG GPDDPKEIMR HSFFSGVNWQ DVYDKKLVPP FKPQVTSETD TRYFDEEFTA QTITITPPEK DDDDGMDCMD NERRPHFPQF SYSASGRE. It is sometimes possible for the material contained within the vial of "RAC-gamma serine/threonine-protein kinase (Akt3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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