A-kinase anchor protein 8 (AKAP8) Recombinant Protein | AKAP8 recombinant protein

Recombinant Dog A-kinase anchor protein 8 (AKAP8), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: A-kinase anchor protein 8 (AKAP8); Recombinant Dog A-kinase anchor protein 8 (AKAP8); partial; AKAP8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 698

• Species: Canis familiaris (Dog) (Canis lupus familiaris)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for AKAP8 recombinant protein

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.

NCBI and Uniprot Product Information

• NCBI GI #: 55742860
• NCBI GeneID: 474362
• NCBI Accession #: NP_001007124.1
• NCBI GenBank Nucleotide #: NM_001007123.1
• UniProt Accession #: Q5VK71
• Molecular Weight: 76,839 Da
• NCBI Official Full Name: A-kinase anchor protein 8
• NCBI Official Synonym Full Names: A-kinase anchoring protein 8
• NCBI Official Symbol: AKAP8
• NCBI Protein Information: A-kinase anchor protein 8
• UniProt Protein Name: A-kinase anchor protein 8
• Protein Family: A-kinase anchor protein
• UniProt Gene Name: AKAP8
• UniProt Synonym Gene Names: AKAP95; AKAP-8; AKAP 95

Uniprot Description

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 ().