Porcine A-kinase anchor protein 13 ELISA Kit | AKAP13 elisa kit
Porcine A-kinase anchor protein 13 (AKAP13) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Uniprot Description
AKAP13: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Nuclear export; GEFs; GEFs, Rac/Rho; Nuclear receptor co-regulator; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 15q24-q25
Cellular Component: cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm
Molecular Function: cAMP-dependent protein kinase activity; metal ion binding; protein binding; protein complex scaffold; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; signal transducer activity
Biological Process: nerve growth factor receptor signaling pathway; nuclear export; positive regulation of apoptosis; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of protein kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
Research Articles on AKAP13
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Product Notes
The Porcine AKAP13 akap13 (Catalog #AAA2604471) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2604471 ELISA Kit recognizes Porcine AKAP13. It is sometimes possible for the material contained within the vial of "A-kinase anchor protein 13, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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