Allograft Inflammatory Factor 1/AIF1 Recombinant Protein | AIF1 recombinant protein

Recombinant Human Allograft Inflammatory Factor 1/AIF1 Protein (C-6His)

Cat. Num. AAA2552340

• Gene Names: AIF1; IBA1; IRT1; AIF-1; IRT-1
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Allograft Inflammatory Factor 1/AIF1; Recombinant Human Allograft Inflammatory Factor 1/AIF1 Protein (C-6His); Allograft Inflammatory Factor 1; AIF-1; Ionized Calcium-Binding Adapter Molecule 1; Protein G1; AIF1; G1; IBA1; AIF1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Ser2-Pro147
• Sequence Length: 93

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for AIF1 recombinant protein

Allograft Inflammatory Factor 1 (AIF1) contains two EF-hand domains and exists as a homodimer. AIF1 can be detected in T-lymphocytes and peripheral blood mononuclear cells. AIF1 functions as actin-binding protein that enhances membrane ruffling and RAC activation and can enhance the actin-bundling activity of LCP1. In addition, AIF1 plays a role in RAC signaling and in phagocytosis and may also in macrophage activation and function. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes and plays a role in vascular inflammation.

NCBI and Uniprot Product Information

• NCBI GI #: 974987466
• NCBI GeneID: 199
• NCBI Accession #: NP_001305899.1
• NCBI GenBank Nucleotide #: NM_001318970.1
• UniProt Accession #: P55008; O43904; Q9UIV4; Q9UKS9; A8K406
• Molecular Weight: Molecular Mass: 17.7 kDa; Actual Protein Molecular Mass: 16 kDa
• NCBI Official Full Name: allograft inflammatory factor 1 isoform 1
• NCBI Official Synonym Full Names: allograft inflammatory factor 1
• NCBI Official Symbol: AIF1
• NCBI Official Synonym Symbols: IBA1; IRT1; AIF-1; IRT-1
• NCBI Protein Information: allograft inflammatory factor 1
• UniProt Protein Name: Allograft inflammatory factor 1
• Protein Family: Apoptosis-inducing factor
• UniProt Gene Name: AIF1
• UniProt Synonym Gene Names: G1; IBA1; AIF-1

NCBI Description

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]

Uniprot Description

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.