Angiotensinogen Protein | AGT protein

Angiotensinogen, Human Plasma

Cat. Num. AAA173525

• Gene Names: Agt; Ang; PAT; ANRT; AngII
• Purity: >= 95% (SDS-PAGE)
• Synonyms: Angiotensinogen; Human Plasma; Serpin A8; Renin substrate; Human Plasma - >=95% (SDS-PAGE); AGT protein

• Purity/Purification: >= 95% (SDS-PAGE)
• Form/Format: Lyophilized in 30mM sodium phosphate pH 6.8; Appearance: White to off-white powder
• Sequence Length: 485

• Source: Human Plasma
• Aliquot: 100ug vial
• Recertification: 3 years
• Protein: 0.46 mg/ml (Before Lyophilization)
• Additional Info: 1st 12 Amino acids: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile (453 total)
• Preparation and Storage: Reconstitute into provided container and centrifuge to ensure full recovery. Aliquot and freeze at -20 degree C after reconstitution. Handle as a potential hazardous substance.

Related Product Information for AGT protein

MyBioSource is a leading supplier of Human Plasma Angiotensinogen (AGT) for life science, laboratory, research and manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available.

Angiotensinogen is a glycoprotein found in plasma and is an essential component of the renin-angiotensin system.

Product Categories/Family for AGT protein

Proteins; Antigens; Standards/controls; Native Proteins; Angiotensinogen

NCBI and Uniprot Product Information

• NCBI GI #: 19705570
• NCBI GeneID: 24179
• NCBI Accession #: NP_602308.1
• NCBI GenBank Nucleotide #: NM_134432.2
• UniProt Accession #: P01019; Q16358; Q16359; Q96F91; P01015
• Molecular Weight: ~61-65,000
• NCBI Official Full Name: angiotensinogen
• NCBI Official Synonym Full Names: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
• NCBI Official Symbol: Agt
• NCBI Official Synonym Symbols: Ang; PAT; ANRT; AngII
• NCBI Protein Information: angiotensinogen; serpin A8; angiotensin II; angiotensinogen (PAT)
• UniProt Protein Name: Angiotensinogen
• Protein Family: Angiotensinogen
• UniProt Gene Name: AGT
• UniProt Synonym Gene Names: SERPINA8; Ang I; Ang II; Ang III; Ang IV
• UniProt Entry Name: ANGT_HUMAN

NCBI Description

plays a role in regulation of blood pressure [RGD, Feb 2006]

Uniprot Description

angiotensin: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1- 8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; growth factor activity; sodium channel regulator activity; hormone activity; type 2 angiotensin receptor binding; superoxide-generating NADPH oxidase activator activity; type 1 angiotensin receptor binding

Biological Process: renal system process; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; establishment of blood-nerve barrier; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; female pregnancy; positive regulation of multicellular organism growth; positive regulation of vasodilation; activation of NF-kappaB transcription factor; ovarian follicle rupture; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of superoxide release; negative regulation of neuron apoptosis; kidney development; positive regulation of NAD(P)H oxidase activity; positive regulation of cytokine production; angiotensin mediated regulation of renal output; response to muscle activity involved in regulation of muscle adaptation; regulation of calcium ion transport; regulation of norepinephrine secretion; negative regulation of tissue remodeling; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure; regulation of vasoconstriction; regulation of transmission of nerve impulse; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); smooth muscle cell differentiation; cytokine secretion; nitric oxide mediated signal transduction; regulation of long-term neuronal synaptic plasticity; peristalsis; cell-matrix adhesion; renin-angiotensin regulation of aldosterone production; positive regulation of cellular protein metabolic process; smooth muscle cell proliferation; cellular lipid metabolic process; excretion; angiotensin maturation; vasodilation; response to salt stress; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; fibroblast proliferation; renin-angiotensin regulation of blood vessel size; regulation of blood pressure; positive regulation of epidermal growth factor receptor signaling pathway; renin-angiotensin regulation of blood volume; regulation of cell growth; angiotensin mediated drinking behavior; artery smooth muscle contraction; aging; positive regulation of fatty acid biosynthetic process; blood vessel development; cellular sodium ion homeostasis; renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure; activation of NF-kappaB-inducing kinase; positive regulation of peptidyl-serine phosphorylation; positive regulation of organ growth; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cellular protein metabolic process; ureteric bud branching; G-protein signaling, coupled to cGMP nucleotide second messenger; blood vessel remodeling; negative regulation of cell growth; response to cold; astrocyte activation; positive regulation of inflammatory response

Disease: Renal Tubular Dysgenesis; Hypertension, Essential