Collagen Type II Native Protein | COL2A1 native protein

Collagen Type II protein

Cat. Num. AAA537376

• Gene Names: COL2A1; AOM; ANFH; SEDC; STL1; COL11A3
• Applications: User optimized
• Synonyms: Collagen Type II; Collagen Type II protein; Cartilage collagen; COL11A3; Chondrocalcin; COL2A1; COL2A1 native protein

• Host: Adult knee cartilage
• Form/Format: Sterile filtered liquid in 0.5M Acetic Acid buffer with 0.01% Sodium Azide as preservative.
• Concentration: 1.0 mg/mL (varies by lot)
• Sequence Length: 1487

• Applicable Applications for COL2A1 native protein: User optimized
• Biohazard: Source material have been for the detection of HIV antibody, Hepatitis B surface antigen, antibody to Hepatitis C, HIV I (antigens), antibody to HTLV-I/II and syphilis by FDA approved methods. All units were found to be non-reactive/negative. Since no test assures complete safety, use appropriate laboratory precautions when handling this product.
• Species: Human
• Protein Type: Native
• Preparation and Storage: Store at 4°C.; ; Use within 6 months from date of opening.

Related Product Information for COL2A1 native protein

Type-II collagen is the basis for articular cartilage and hyaline cartilage. It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage. Type II collagen does form fibers. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.

Product Categories/Family for COL2A1 native protein

Cancer; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 95132445
• NCBI GeneID: 1280
• UniProt Accession #: P02458; Q12985; Q14009; Q14044; Q14045; Q14046; Q14047; Q14056; Q14058; Q16672; Q1JQ82; A6NGA0
• NCBI Official Full Name: Collagen, type II, alpha 1
• NCBI Official Synonym Full Names: collagen, type II, alpha 1
• NCBI Official Symbol: COL2A1
• NCBI Official Synonym Symbols: AOM; ANFH; SEDC; STL1; COL11A3
• NCBI Protein Information: collagen alpha-1(II) chain
• UniProt Protein Name: Collagen alpha-1(II) chain
• UniProt Gene Name: COL2A1
• UniProt Entry Name: CO2A1_HUMAN

NCBI Description

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

COL2A1: the alpha-1 chain of type II collagen, an extra-cellular matrix protein found in cartilage and the vitreous humor of the eye. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Chondrocalcin is the calcium binding C-propeptide of this collagen molecule. Defects in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. There are two transcripts identified for this gene. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.11

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type II; extracellular region; basement membrane

Molecular Function: identical protein binding; platelet-derived growth factor binding; metal ion binding; extracellular matrix structural constituent conferring tensile strength

Biological Process: heart morphogenesis; axon guidance; proteoglycan metabolic process; extracellular matrix organization and biogenesis; inner ear morphogenesis; collagen fibril organization; central nervous system development; palate development; notochord development; limb bud formation; extracellular matrix disassembly; collagen catabolic process; sensory perception of sound; visual perception; regulation of gene expression; cartilage development; tissue homeostasis; chondrocyte differentiation; skeletal development; endochondral ossification; cartilage condensation

Disease: Achondrogenesis, Type Ii; Kniest Dysplasia; Epiphyseal Dysplasia, Multiple, With Myopia And Conductive Deafness; Spondyloperipheral Dysplasia; Legg-calve-perthes Disease; Osteoarthritis With Mild Chondrodysplasia; Stickler Syndrome, Type I; Czech Dysplasia; Platyspondylic Lethal Skeletal Dysplasia, Torrance Type; Otospondylomegaepiphyseal Dysplasia; Spondyloepimetaphyseal Dysplasia, Strudwick Type; Spondyloepiphyseal Dysplasia Congenita; Avascular Necrosis Of Femoral Head, Primary; Stickler Syndrome, Type I, Nonsyndromic Ocular