Adenosine A1 receptor Blocking Peptide | ADORA1 blocking peptide
Adenosine A1 receptor Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Apoptosis; Endoplasmic reticulum; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: asymmetric synapse; axolemma; basolateral plasma membrane; cell soma; dendritic spine; endoplasmic reticulum; integral to plasma membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane; terminal button
Molecular Function: adenosine receptor activity, G-protein coupled; G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; heat shock protein binding; heterotrimeric G-protein binding; phospholipase C activity; protein binding; protein heterodimerization activity; purine nucleoside binding
Biological Process: activation of MAPKK activity; adenosine receptor signaling pathway; cell-cell signaling; cognition; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response; lipid catabolic process; negative regulation of acute inflammatory response; negative regulation of apoptosis; negative regulation of blood pressure; negative regulation of cell proliferation; negative regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of glutamate secretion; negative regulation of hormone secretion; negative regulation of leukocyte migration; negative regulation of lipid catabolic process; negative regulation of neurotrophin production; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; negative regulation of vasodilation; nervous system development; neurological control of breathing; phagocytosis; positive regulation of blood pressure; positive regulation of epidermal growth factor receptor activity; positive regulation of nucleoside transport; positive regulation of peptide secretion; positive regulation of potassium ion transport; positive regulation of protein amino acid dephosphorylation; protein targeting to membrane; regulation of excitatory postsynaptic membrane potential; regulation of glomerular filtration; regulation of sensory perception of pain; relaxation of vascular smooth muscle; response to hypoxia; signal transduction; thermoregulation
Research Articles on ADORA1
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Product Notes
The ADORA1 adora1 (Catalog #AAA425566) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The Adenosine A1 receptor Immunizing Peptide reacts with Human, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: NDHFRCQPAP PIDED. It is sometimes possible for the material contained within the vial of "Adenosine A1 receptor, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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