Mouse adenosine deaminase, RNA-specific ELISA Kit | ADAR elisa kit
Mouse Double-stranded RNA-specific adenosine deaminase, ADAR ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ADAR: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter.
Protein type: Nucleolus; EC 3.5.4.37; RNA-binding; Hydrolase; RNA processing
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus
Molecular Function: adenosine deaminase activity; double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; hydrolase activity; RNA binding; metal ion binding; double-stranded RNA binding
Biological Process: positive regulation of viral genome replication; base conversion or substitution editing; transcription, DNA-dependent; in utero embryonic development; immune system process; response to virus; miRNA-mediated gene silencing, miRNA loading onto RISC; somatic diversification of immune receptors via somatic mutation; adenosine to inosine editing; RNA processing; osteoblast differentiation; miRNA-mediated gene silencing, production of miRNAs; regulation of transcription, DNA-dependent; negative regulation of viral genome replication; pre-microRNA processing; protein import into nucleus; erythrocyte differentiation; innate immune response; RNA-mediated gene silencing; hemopoietic progenitor cell differentiation; protein export from nucleus; mRNA processing; defense response to virus; negative regulation of apoptosis