C-C motif chemokine 22 (CCL22) Recombinant Protein | CCL22 recombinant protein

Recombinant Human C-C motif chemokine 22 (CCL22)

• Gene Names: ADAM11; MDC
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C-C motif chemokine 22 (CCL22); Recombinant Human C-C motif chemokine 22 (CCL22); C-C motif chemokine 22; CC chemokine STCP-1; MDC(1-69); Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1Cleaved into the following 3 chains:; 1. MDC(3-69); 2. MDC(5-69); 3. MDC(7-69); CCL22 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 226-734
• Sequence: QVRRG HPTVHSETKY VELIVINDHQ LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTN
• Sequence Length: 509

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 4585710
• NCBI GeneID: 4185
• NCBI Accession #: NP_002381.2
• NCBI GenBank Nucleotide #: NM_002390.4
• UniProt Accession #: O75078; Q14808; Q14809; Q14810; AAB29191
• Molecular Weight: 57,911 Da
• NCBI Official Full Name: disintegrin and metalloproteinase domain-containing protein 11 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 11
• NCBI Official Symbol: ADAM11
• NCBI Official Synonym Symbols: MDC
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 11; ADAM 11
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 11
• Protein Family: C-C motif chemokine
• UniProt Gene Name: ADAM11
• UniProt Synonym Gene Names: MDC; ADAM 11; MDC
• UniProt Entry Name: ADA11_HUMAN

NCBI Description

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAM11: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: extracellular matrix; integral to membrane; plasma membrane

Molecular Function: integrin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: integrin-mediated signaling pathway; proteolysis