Fish A Disintegrin and Metalloprotease 11 ELISA Kit | ADAM11 elisa kit

Fish A Disintegrin and Metalloprotease 11 ELISA Kit

• Gene Names: ADAMTS5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
• Reactivity: Fish
• Synonyms: A Disintegrin and Metalloprotease 11; Fish A Disintegrin and Metalloprotease 11 ELISA Kit; ADAM11 elisa kit

• Reactivity: Fish
• Sequence Length: 930

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 317373326
• NCBI GeneID: 11096
• UniProt Accession #: Q9UNA0; Q52LV4; Q9UKP2
• Molecular Weight: 101,718 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 5
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 5
• NCBI Official Symbol: ADAMTS5
• NCBI Official Synonym Symbols: ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 5
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: ADAMTS5
• UniProt Synonym Gene Names: ADAMTS11; ADMP2; ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADAM-TS 11; ADAMTS-11
• UniProt Entry Name: ATS5_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Protein type: Motility/polarity/chemotaxis; Secreted; Protease; Extracellular matrix; EC 3.4.24.-; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region

Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; post-translational protein modification; proteolysis