NCBI and Uniprot Product Information
Uniprot Description
ADA: a enzyme that converts adenosine + H2O into inosine + NH3. Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues. Genetic ADA deficiencies are a cause of autosomal recessive severe combined immuno-deficiency (SCID). Hereditary hemolytic anemia is caused by expression levels in erythrocytes 50-70 times greater than the norm.
Protein type: Nucleotide Metabolism - purine; EC 3.5.4.4; Hydrolase
Cellular Component: cell junction; cell soma; cell surface; cytoplasm; cytoplasmic vesicle; dendrite cytoplasm; external side of plasma membrane; extracellular space; lysosome; membrane; plasma membrane
Molecular Function: adenosine deaminase activity; deaminase activity; hydrolase activity; metal ion binding; purine nucleoside binding; zinc ion binding
Biological Process: adenosine catabolic process; adenosine metabolic process; alveolus development; cell adhesion; dATP catabolic process; deoxyadenosine catabolic process; embryonic gut development; germinal center B cell differentiation; histamine secretion; hypoxanthine biosynthetic process; hypoxanthine salvage; in utero embryonic development; inosine biosynthetic process; liver development; lung development; negative regulation of adenosine receptor signaling pathway; negative regulation of apoptosis; negative regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of inflammatory response; negative regulation of leukocyte migration; negative regulation of mature B cell apoptosis; nucleotide metabolic process; Peyer's patch development; placenta development; positive regulation of alpha-beta T cell differentiation; positive regulation of B cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of germinal center formation; positive regulation of heart rate; positive regulation of smooth muscle contraction; positive regulation of T cell activation; positive regulation of T cell differentiation; positive regulation of T cell differentiation in the thymus; positive regulation of T cell receptor signaling pathway; purine nucleotide salvage; purine ribonucleoside monophosphate biosynthetic process; regulation of cell-cell adhesion mediated by integrin; regulation of T cell differentiation; response to hypoxia; response to morphine; response to vitamin E; T cell activation; trophectodermal cell differentiation; xanthine biosynthetic process
Research Articles on Ada
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Product Notes
The Mouse Ada ada (Catalog #AAA2886951) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2886951 ELISA Kit recognizes Mouse Ada. It is sometimes possible for the material contained within the vial of "Adenosine deaminase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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