Activin receptor type-2B Recombinant Protein | Acvr2b recombinant protein
Activin receptor type-2B
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
plays a role in reproductive physiology and endocrinology [RGD, Feb 2006]
Uniprot Description
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.
Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Kinase, protein; Membrane protein, integral; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily
Cellular Component: cytoplasm; protein complex; receptor complex
Molecular Function: activin binding; growth factor binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transforming growth factor beta binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; activin receptor signaling pathway; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; insulin secretion; kidney development; lung development; lymphangiogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; organ growth; palate development; pancreas development; pattern specification process; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; protein amino acid phosphorylation; regulation of signal transduction; regulation of transcription, DNA-dependent; response to glucose stimulus; signal transduction; skeletal development; skeletal morphogenesis
Research Articles on Acvr2b
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Product Notes
The Acvr2b acvr2b (Catalog #AAA7042076) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-513aa; full length protein. The amino acid sequence is listed below: SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE PGGPEVTYEP PPTAPTLLTV LAYSLLPIGG LSLIVLLAFW MYRHRKPPYG HVDIHEDPGP PPPSPLVGLK PLQLLEIKAR GRFGCVWKAQ LMNDFVAVKI FPLQDKQSWQ SEREIFSTPG MKHENLLQFI AAEKRGCSNL EVELWLITAF HDKGSLTDYL KGNIITWNEL CHVAETMSRG LSYLHEDVPW CRGEGHKPSI AHRDFKSKNV LLKSDLTAVL ADFGLAVRFE PGKPPGDTHG QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELV SRCKAADGPV DEYMLPFEEE IGQHPSLEEL QEVVVHKKMR PTIKDHWLKH PGLAQLCVTI EECWDHDAEA RLSAGCVEER VSLIRRSVNS STSDCLVSLV TSVTNVDLLP KESSI. It is sometimes possible for the material contained within the vial of "Activin receptor type-2B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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