Activin receptor type-1C Recombinant Protein | Acvr1c recombinant protein
Activin receptor type-1C
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
may play a role in neuronal maturation [RGD, Feb 2006]
Uniprot Description
ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily
Cellular Component: activin receptor complex; cell surface; cytoplasm; plasma membrane
Molecular Function: activin binding; activin receptor activity, type I; ATP binding; growth factor binding; metal ion binding; protein serine/threonine kinase activity; SMAD binding
Biological Process: apoptotic nuclear changes; cell differentiation; cerebellum development; determination of left/right symmetry; hippocampus development; in utero embryonic development; midbrain development; negative regulation of insulin secretion; ovarian follicle development; positive regulation of caspase activity; protein amino acid phosphorylation; regulation of apoptosis; response to dietary excess; response to drug; response to glucose stimulus; response to insulin stimulus; response to lipid; response to organic cyclic substance; sequestering of lipid; transforming growth factor beta receptor complex assembly
Research Articles on Acvr1c
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Product Notes
The Acvr1c acvr1c (Catalog #AAA7042070) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-493aa; full length protein. The amino acid sequence is listed below: LKCVCLLCDS SNFTCQTEGA CWASVMLTNG KEQVSKSCVS LPELNAQVFC HSSNNVTKTE CCFTDFCNNI TQHLPTASPD APRLGPTELT VVITVPVCLL SIAAMLTIWA CQDRQCTYRK TKRHNVEEPL AEYSLVNAGK TLKDLIYDAT ASGSGSGPPL LVQRTIARTI VLQEIVGKGR FGEVWHGRWC GEDVAVKIFS SRDERSWFRE AEIYQTVMLR HENILGFIAA DNKDNGTWTQ LWLVSEYHEQ GSLYDYLNRN IVTVAGMVKL ALSIASGLAH LHMEIVGTQG KPAIAHRDIK SKNILVKKCD TCAIADLGLA VKHDSIMNTI DIPQNPKVGT KRYMAPEMLD DTMNVNIFES FKRADIYSVG LVYWEIARRC SVGGLVEEYQ LPYYDMVPSD PSIEEMRKVV CDQKLRPNLP NQWQSCEALR VMGRIMRECW YANGAARLTA LRVKKTISQL CVKEDCKA. It is sometimes possible for the material contained within the vial of "Activin receptor type-1C, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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