Alpha-conotoxin Vc1A Recombinant Protein | ACV1 recombinant protein
Recombinant Conus victoriae Alpha-conotoxin Vc1A
NCBI and Uniprot Product Information
Uniprot Description
Function: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide (produced without hydroxyproline, nor 4-carboxyglutamate) is a neuronal nAChR antagonist that acts as a powerful analgesic. It blocks nAChRs composed of alpha-3 or -5/beta-2 (IC50=7.2 µM), alpha-3/beta-2 (IC50=7.3 µM), alpha-3/beta-4 (IC50=4.2 µM), alpha-3 or -5/beta-4 (IC50<30 µM), alpha-4/beta-2 (IC50<30 µM), alpha-4/beta-4 (IC50<30 µM) and alpha/beta/gamma/delta (IC50<30 µM) subunits. Ref.1 Ref.3
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom duct.
Domain: The cysteine framework is I (CC-C-C).
Pharmaceutical use: Failed in phase II clinical trial. Was tested by Metabolic under the name ACV1 to treat neuropathic pain.
Sequence similarities: Belongs to the conotoxin A superfamily.
Mass spectrometry: Molecular mass is 1866.5 Da from positions 50 - 65. Determined by ESI. Ref.2Molecular mass is 1866 Da from positions 50 - 65. Determined by ESI. Ref.5Molecular mass is 1809.7 Da from positions 50 - 65. Determined by ESI. Without hydroxyPro-55, nor gamma-carboxyglutamic acid. Ref.5Molecular mass is 1821.6 Da from positions 50 - 65. Determined by ESI. With hydroxyPro-55, but without gamma-carboxyglutamic acid. Ref.5
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Product Notes
The Alpha-conotoxin Vc1A acv1 (Catalog #AAA1138352) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 50-65aa; Cytoplasmic domain. The amino acid sequence is listed below: G CCSDPRCNYD HPEIC. It is sometimes possible for the material contained within the vial of "Alpha-conotoxin Vc1A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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