Vitronectin Active Protein | VTN active protein
Recombinant Human Vitronectin; Human Vitronectin
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subunit structure: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP. Ref.9 Ref.10 Ref.15 Ref.16
Subcellular location: Secreted › extracellular space.
Tissue specificity: Plasma.
Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Post-translational modification: Sulfated on 2 tyrosine residues.N- and O-glycosylated
By similarity. Ref.22 Ref.25Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.Phosphorylation sites are present in the extracellular medium.
Sequence similarities: Contains 4 hemopexin repeats.Contains 1 SMB (somatomedin-B) domain.
Research Articles on VTN
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Product Notes
The VTN vtn (Catalog #AAA691940) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: DQESCKGRCT EGFNVDKKCQ CDELCSYYQS CCTDYTAECK PQVTRG DVFT MPEDEYTVYD DGEEKNNATV HEQVGGPSLT SDLQAQSKGN P EQTPVLKPE EEAPAPEVGA SKPEGIDSRP ETLHPGRPQP PAEEELC SGK PFDAFTDLKN GSLFAFRGQY CYELDEKAVR PGYPKLIRDV WG IEGPIDAA FTRINCQGKT YLFKGSQYWR FEDGVLDPDY PRNISDGF DG IPDNVDAALA LPAHSYSGRE RVYFFKGKQY WEYQFQHQPS QEE CEGSSLS AVFEHFAMMQ RDSWEDIFEL LFWGRTSAGT RQPQFISRD W HGVPGQVDAA MAGRIYISGM APRPSLAKKQ RFRHRNRKGY RSQR GHSRGR NQNSRRPSRA TWLSLFSSEE SNLGANNYDD YRMDWLVPAT CEPIQSVFFF SGDKYYRVNL RTRRVDTVDP PYPRSIAQYW LGCPA PGHL. It is sometimes possible for the material contained within the vial of "Vitronectin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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