Neurexin 2 alpha, Isoform 2, Fc Chimera Active Protein
Neurexin 2 alpha, Isoform 2, Recombinant, Human, Fc Chimera (Neurexin-2-alpha, Neurexin II-alpha, NRXN2, KIAA0921)
Purity
Highly Purified~95% (SDS-PAGE)
Synonyms
Neurexin 2 alpha; Isoform 2; Fc Chimera; Recombinant; Human; Fc Chimera (Neurexin-2-alpha; Neurexin II-alpha; NRXN2; KIAA0921); Fc Chimera active protein
Purity/Purification
Highly Purified
~95% (SDS-PAGE)
~95% (SDS-PAGE)
Form/Format
Supplied as a lyophilized powder in PBS. Reconstitute with PBS to 100ug/ml.BSA free.
Biological Activity
Measured by its binding ability in a functional ELISA. When recombinant human NRXN2a Fc Chimera is coated at 2ug/ml, biotinylated recombinant rat NXPH-1 binds with an apparent KD <10nM.
Endotoxin Level
1EU/1ug (LAL)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Neurexin 2 alpha, Isoform 2, Fc Chimera active protein
Neurexin 2, also known as NRXN2, is a neuronal type I transmembrane molecule that is encoded by one of three Neurexin genes (1, 2). Mature human Neurexin 2a is an ~200kD N- and O-glycosylated protein with a 1608aa extracellular domain (ECD) and a 55 aa cytoplasmic domain. The ECD contains six LNS domains interspersed with three EGF-like domains and a juxtamembrane O-glycosylation region (1-3). The ECD of human Neurexin 2a shares 98% and 99% aa sequence identity with mouse and rat Neurexin 2a, respectively. Transcription of the Neurexin 2 gene from an internal promoter gives rise to Neurexin 2B which lacks the first five LNS domains and all of the EGF-like domains (3, 4). Human Neurexin 2a is combinatorially spliced at five canonical sites in the ECD, giving rise to nearly 200 potential isoforms (4). This recombinant protein (isoform 2 according to SwissProt # Q9P2S2) does not contain inserts at splice sites 1, 2, 3,or 4. Neurexin 2a is primarily expressed in the brain where it is localized to presynaptic terminals (3, 5, 6). It binds Neurexophilin 1 and 3, Neuroligin 2, and Dystroglycan (7-9). Only Neurexin 2 isoforms that lack the insert at splice site 4 additionally bind LRRTM2 (10). The interaction between Neurexins and Neuroligins is complex and is restricted to particular combinations of splice forms of each binding partner (11). These interactions promote the differentiation and maintenance of postsynaptic GABA and NMDA but not AMPA terminals (8, 12). At presynaptic terminals as well as in pituitary melanotrophs, alpha Neurexins are required for coupling voltage- dependent calcium channel signaling to neurotransmitter or hormone release (13-15).
Product Categories/Family for Neurexin 2 alpha, Isoform 2, Fc Chimera active protein
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Product Notes
The Neurexin 2 alpha, Isoform 2, Fc Chimera (Catalog #AAA637309) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Neurexin 2 alpha, Isoform 2, Fc Chimera, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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