Myeloperoxidase Active Protein | Mpo active protein

Myeloperoxidase (MPO) Antigen, Human Neutrophil - pANCA

Cat. Num. AAA173160

• Gene Names: Mpo; mKIAA4033
• Purity: >= 96% (SDS-PAGE)
• Synonyms: Myeloperoxidase; Myeloperoxidase (MPO) Antigen; Human Neutrophil - pANCA; MPO; pANCA; Myeloperoxidase Antigen (MPO); pANCA - Human - >=96% (SDS-PAGE) - Liquid; Mpo active protein

• Purity/Purification: >= 96% (SDS-PAGE)
• Form/Format: Liquid; Appearance: Clear, greenish Liquid
• Sequence Length: 718

• Source: Human Neutrophils
• EC Number: 1.11.2.2
• Unit Definition: One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 degree C.
• Specific Activity: >= 1,000 U/mg protein
• RZ Value: >= 0.8 (A₄₃₀/A₂₈₀)
• Recertification: 2 years
• Protein: 1.0 - 2.0 mg/mL (A₂₈₀, E^0.1%=1.45)
• CAS Number: 9003-99-0
• Activity: >= 1,000 U/mL
• Preparation and Storage: 2-8 degree C

Related Product Information for Mpo active protein

MyBioSource is the largest primary manufacturer of Myeloperoxidase (MPO) enzymes for medical research and manufacturing globally.

Custom preparations, technical support, bulk quantities and aliquoting available.

Rz is an abbreviation for Reinheitszahl (purity number). It is the ratio of absorbance at 430 nm (heme)/ 280 nm (total protein). It is a measure of the purity of the enzyme. Anything above 0.8 is highly pure.

MPO is a peroxidase enzyme occurs the most in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. Myeloperoxidase has a green heme pigment and is found in pus and some forms of mucus. It is recognized as an important factor in many inflammatory diseases such as cardiovascular and neurological diseases. MPO-specific imaging agents would thus be highly useful to identify early disease, monitor disease progression, and quantify treatment effects.

Product Categories/Family for Mpo active protein

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Myeloperoxidase (mpo) Antigen; Panca

NCBI and Uniprot Product Information

• NCBI GI #: 226823250
• NCBI GeneID: 17523
• NCBI Accession #: NP_034954.2
• NCBI GenBank Nucleotide #: NM_010824.2
• UniProt Accession #: P05164; Q5NCP1; P11247
• Molecular Weight: 81,182 Da
• NCBI Official Full Name: myeloperoxidase
• NCBI Official Synonym Full Names: myeloperoxidase
• NCBI Official Symbol: Mpo
• NCBI Official Synonym Symbols: mKIAA4033
• NCBI Protein Information: myeloperoxidase
• UniProt Protein Name: Myeloperoxidase
• Protein Family: Myeloperoxidase
• UniProt Gene Name: Mpo
• UniProt Synonym Gene Names: MPO
• UniProt Entry Name: PERM_MOUSE

Uniprot Description

MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.11.2.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule

Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding

Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis

Disease: Myeloperoxidase Deficiency; Alzheimer Disease