Interleukin 13 Active Protein | IL13 active protein

Interleukin 13, Recombinant, Human (IL-13)

Cat. Num. AAA650504

• Gene Names: IL13; ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789
• Purity: Highly Purified; ~95% (SDS-PAGE)
• Synonyms: Interleukin 13; Recombinant; Human (IL-13); IL13 active protein

• Purity/Purification: Highly Purified; ~95% (SDS-PAGE)
• Form/Format: Supplied as a lyophilized powder. Reconstitute in sterile,ddH2O to 0.1-1mg/ml. Further dilutions should be made in low endotoxin medium or buffered solution with FBS or tissue culture grade BSA.

• Biological Activity: ED50 range =2.0-6.0ng/ml, determined by the dose dependent proliferation of human TF-1 cells. The optimal concentration for each specific application should be determined by an initial dose response assay.
• Endotoxin Level: ~0.1ng/ug
• Preparation and Storage: Lyophilized powder may be stored at -70 degree C. Reconstitute to nominal volume by adding ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for IL13 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 26787978
• NCBI GeneID: 3596
• NCBI Accession #: NP_002179.2
• NCBI GenBank Nucleotide #: NM_002188.2
• UniProt Accession #: P35225; O43644; Q4VB52; Q9UDC7; Q4VB50; Q4VB51; Q4VB53
• Molecular Weight: 17kD
• NCBI Official Full Name: interleukin-13
• NCBI Official Synonym Full Names: interleukin 13
• NCBI Official Symbol: IL13
• NCBI Official Synonym Symbols: ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789
• NCBI Protein Information: interleukin-13; allergic rhinitis; OTTHUMP00000066048; Bronchial hyperresponsiveness-1 (bronchial asthma)
• UniProt Protein Name: Interleukin-13
• Protein Family: Interleukin
• UniProt Gene Name: IL13
• UniProt Synonym Gene Names: NC30
• UniProt Entry Name: IL13_HUMAN

NCBI Description

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq]

Uniprot Description

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subunit structure: Interacts with IL13RA2.

Subcellular location: Secreted.

Involvement in disease: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [

MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Sequence similarities: Belongs to the IL-4/IL-13 family.

Caution: It is uncertain whether Met-1 or Met-15 is the initiator.

Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.