G-CSF Receptor Active Protein | CSF3R active protein

G-CSF Receptor, Recombinant, Human (G-CSFR, GCSFR, CSF3R, Granulocyte Colony-stimulating Factor Receptor, G-CSF-R, CD114)

Cat. Num. AAA635978

• Gene Names: CSF3R; CD114; GCSFR
• Purity: Purified; 97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
• Synonyms: G-CSF Receptor; Recombinant; Human (G-CSFR; GCSFR; CSF3R; Granulocyte Colony-stimulating Factor Receptor; G-CSF-R; CD114); CSF3R active protein

• Purity/Purification: Purified; 97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
• Form/Format: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS with BSA as a carrier protein. Reconstitute at 100ug/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.

• Activity: Measured by its ability to inhibit the G­CSF­induced proliferation of NFS­60 mouse myeloid cells.
• Endotoxin Level: 1.0 EU/ug of the protein by the LAL method.
• Preparation and Storage: Lyophilized powder is shipped at ambient temperature. Stability is 12 months from date of receipt, ­20 to ­70 degree C as supplied. 1 month, 2 to 8 degree C under sterile conditions after reconstitution. 3 months, ­20 to ­70 degree C under sterile conditions after reconstitution.

Related Product Information for CSF3R active protein

Granulocyte Colony Stimulating Factor (G­CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. G­CSF plays an important role in defense against infection, in inflammation and repair, and in the maintenance of steady state hematopoiesis. Recombinant human G­CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant.

G­CSF R is expressed in mature neutrophils, neutrophilic precursors, myeloid leukemia cells, and placenta. Binding of G­CSF to its receptor induces dimerization or oligomerization of the receptor activating cytoplasmic tyrosine kinases. Signal transduction from pathways that involve Janus tyrosine kinases/signal transducer and activator of transcription proteins (Jak1, Jak2, and Tyk2/STAT3, STAT3, and STATG), src­related protein tyrosine kinases (Lyn and Syk), Ras/MAP kinase, and phosphatidylinositol have been reported to be activated upon G­CSF stimulation (1).

Product Categories/Family for CSF3R active protein

Molecular Biology; MB-Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 24496783
• NCBI GeneID: 1441
• NCBI Accession #: NP_724781.1
• NCBI GenBank Nucleotide #: NM_156039.3
• UniProt Accession #: Q99062
• Molecular Weight: ~100kD
• NCBI Official Full Name: granulocyte colony-stimulating factor receptor isoform c
• NCBI Official Synonym Full Names: colony stimulating factor 3 receptor (granulocyte)
• NCBI Official Symbol: CSF3R
• NCBI Official Synonym Symbols: CD114; GCSFR
• NCBI Protein Information: granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor
• UniProt Protein Name: Granulocyte colony-stimulating factor receptor
• Protein Family: Granulocyte colony-stimulating factor receptor
• UniProt Gene Name: CSF3R
• UniProt Synonym Gene Names: GCSFR; G-CSF receptor; G-CSF-R
• UniProt Entry Name: CSF3R_HUMAN

NCBI Description

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

Uniprot Description

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity

Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; signal transduction; cell adhesion

Disease: Neutrophilia, Hereditary