Fibroblast Growth Factor 20 Active Protein | FGF20 active protein

Fibroblast Growth Factor 20, Human (FGF20) Recombinant

Cat. Num. AAA636884

• Gene Names: FGF20; FGF-20
• Purity: Highly Purified; 90% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug)
• Synonyms: Fibroblast Growth Factor 20; Human (FGF20) Recombinant; FGF20 active protein

• Purity/Purification: Highly Purified; 90% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug)
• Form/Format: Supplied as a lyophilized powder in 20mM Tris, pH 7.6, 1.5M sodium chloride. Reconstitute in sterile dH2O to a concentration of 0.1-1mg/ml. This solution can then be diluted into other aqueous buffers.

• Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is 10ng/ml, corresponding to a speci c activity of 1 x 10e5 units/mg.
• Country of Origin: USA
• Reconstitution: Reconstitute in sterile dH2O to a concentration of 0.1-1mg/ml. This solution can then be diluted into other aqueous buffers.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for FGF20 active protein

The FGF family plays important roles in morphogenesis, cellular differentiation, angiogenesis, tissue remodeling, in ammation and oncogenesis. Fibroblast Growth Factor-20 (FGF-20) is a newly discovered neurotrophic factor belonging to the FGF family. FGF-20 is most similar to FGF-9 and FGF-16. Recombinant Human FGF-20 is a 23.2kDa protein containing 209 amino acid residues.

Product Categories/Family for FGF20 active protein

Growth Factors; Cytokines; Growth Factors-FGF

NCBI and Uniprot Product Information

• NCBI GI #: 9789947
• NCBI GeneID: 26281
• NCBI Accession #: NP_062825.1
• NCBI GenBank Nucleotide #: NM_019851.2
• UniProt Accession #: Q9NP95; B2RPH5
• Molecular Weight: 23.2kD
• NCBI Official Full Name: fibroblast growth factor 20
• NCBI Official Synonym Full Names: fibroblast growth factor 20
• NCBI Official Symbol: FGF20
• NCBI Official Synonym Symbols: FGF-20
• NCBI Protein Information: fibroblast growth factor 20
• UniProt Protein Name: Fibroblast growth factor 20
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF20
• UniProt Synonym Gene Names: FGF-20
• UniProt Entry Name: FGF20_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

Uniprot Description

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; inner ear receptor cell differentiation; cell-cell signaling; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; regulation of cardiac muscle cell proliferation; signal transduction

Disease: Renal Hypodysplasia/aplasia 2