Ciliary Neurotropic Factor Active Protein | Cntf active protein
Ciliary Neurotropic Factor, Recombinant, Human (CNTF)
Purity
Highly Purified~98% (SDS PAGE, HPLC)
Synonyms
Ciliary Neurotropic Factor; Recombinant; Human (CNTF); Cntf active protein
Purity/Purification
Highly Purified
~98% (SDS PAGE, HPLC)
~98% (SDS PAGE, HPLC)
Form/Format
Supplied as a lyophilized powder in 5mM sodium phosphate, pH 7.5, 5mM NaCl. Reconstitute with 5mM sodium phosphate, pH 7.5, to a concentration of 0.1-1.0 mg/ml
Activity
ED50 <2.0ng/ml (> 5 x 10e5 units/mg). The biological activity was determined by measuring the dose-dependent proliferation of human TF-a cells. Ciliary Neurotropic Factor (CNTF), also known as Membrane-Associated Neurotransmitter Stimulating Factor (MANS), is produced by Schwann cells in peripheral nervous tissue and astrocytes in the central nervous system. Ciliary Neurotrophic Factor promotes the growth and survival of many neural derived cells including parasympathetic, sympathetic, sensory and spinal motor neurons and chick ciliary neurons in vitro.
Endotoxin Level
<0.1 ng/ug
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with 5mM sodium phosphate, pH 7.5. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Product Categories/Family for Cntf active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
22.9kD, 200 amino acid residues
NCBI Official Full Name
ciliary neurotrophic factor
NCBI Official Synonym Full Names
ciliary neurotrophic factor
NCBI Official Symbol
Cntf
NCBI Protein Information
ciliary neurotrophic factor; ciliary neurotropic factor
UniProt Protein Name
Ciliary neurotrophic factor
Protein Family
UniProt Gene Name
Cntf
UniProt Entry Name
CNTF_RAT
NCBI Description
a cytokine involved in neuronal degeneration and adipocyte gene expression [RGD]
Uniprot Description
Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Subcellular location: Cytoplasm.
Tissue specificity: Nervous system.
Sequence similarities: Belongs to the CNTF family.
Research Articles on Cntf
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Product Notes
The Cntf cntf (Catalog #AAA651059) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ciliary Neurotropic Factor, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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