ATP-citRate synthase (ACLY) Recombinant Protein | ACLY recombinant protein

Recombinant Human ATP-citRate synthase (ACLY), partial

Cat. Num. AAA9423905

• Gene Names: ACLY; ACL; ATPCL; CLATP
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: ATP-citRate synthase (ACLY); Recombinant Human ATP-citRate synthase (ACLY); partial; ATP-citrate (pro-S-)-lyase; ACLY recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Partial, 4-265aa

• Tag Info: N-terminal 6xHis-SUMO-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

Related Product Information for ACLY recombinant protein

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

NCBI and Uniprot Product Information

• NCBI GI #: 38569421
• NCBI GeneID: 47
• NCBI Accession #: NP_001087.2
• NCBI GenBank Nucleotide #: NM_001096.2
• UniProt Accession #: P53396; Q13037; Q9BRL0; B4DIM0; B4E3P0
• Molecular Weight: 45.46 kDa
• NCBI Official Full Name: ATP-citrate synthase isoform 1
• NCBI Official Synonym Full Names: ATP citrate lyase
• NCBI Official Symbol: ACLY
• NCBI Official Synonym Symbols: ACL; ATPCL; CLATP
• NCBI Protein Information: ATP-citrate synthase
• UniProt Protein Name: ATP-citrate synthase
• Protein Family: ATP-citrate synthase
• UniProt Gene Name: ACLY
• UniProt Synonym Gene Names: ACL

NCBI Description

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: citrate lyase complex; cytosol; extracellular region; membrane; nucleoplasm; plasma membrane

Molecular Function: ATP binding; ATP citrate synthase activity; protein binding

Biological Process: acetyl-CoA biosynthetic process; acyl-CoA biosynthetic process; cholesterol biosynthetic process; citrate metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; neutrophil degranulation; oxaloacetate metabolic process; positive regulation of cellular metabolic process