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Human Acetylcholinesterase antibody ELISA Kit | ACHE.Ab elisa kit

Human Acetylcholinesterase antibody ELISA Kit

Gene Names
ACHE; YT; ACEE; ARACHE; N-ACHE
Reactivity
Human
Synonyms
Acetylcholinesterase antibody; Human Acetylcholinesterase antibody ELISA Kit; ACHE.Ab; ACHE.Ab elisa kit
Ordering
For Research Use Only!
Reactivity
Human
Sequence Length
72
Detection Range
3.12-200 U/mL
Preparation and Storage
For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
43
Molecular Weight
58,352 Da
NCBI Official Full Name
acetylcholinesterase, partial
NCBI Official Synonym Full Names
acetylcholinesterase (Yt blood group)
NCBI Official Symbol
ACHE
NCBI Official Synonym Symbols
YT; ACEE; ARACHE; N-ACHE
NCBI Protein Information
acetylcholinesterase
UniProt Protein Name
Acetylcholinesterase
UniProt Gene Name
ACHE
UniProt Synonym Gene Names
AChE
UniProt Entry Name
ACES_HUMAN

NCBI Description

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

Uniprot Description

ACHE: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; EC 3.1.1.7; Lipid Metabolism - glycerophospholipid; Hydrolase

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: basal lamina; cell junction; cell surface; extracellular region; extracellular space; Golgi apparatus; membrane; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; synapse

Molecular Function: acetylcholine binding; acetylcholinesterase activity; beta-amyloid binding; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein self-association; serine hydrolase activity

Biological Process: acetylcholine catabolic process; acetylcholine catabolic process in synaptic cleft; amyloid precursor protein metabolic process; cell adhesion; cell proliferation; DNA replication; glycerophospholipid biosynthetic process; muscle development; negative regulation of synaptic transmission, cholinergic; nervous system development; neurotransmitter biosynthetic process; neurotransmitter receptor biosynthetic process; osteoblast development; phosphatidylcholine biosynthetic process; phospholipid metabolic process; positive regulation of protein secretion; protein tetramerization; receptor internalization; regulation of receptor recycling; response to wounding; retina development in camera-type eye; synaptic transmission; synaptogenesis

Disease: Yt Blood Group Antigen

Research Articles on ACHE.Ab

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Product Notes

The Human ACHE.Ab ache (Catalog #AAA2886406) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2886406 ELISA Kit recognizes Human ACHE.Ab. It is sometimes possible for the material contained within the vial of "Acetylcholinesterase antibody, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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