ACADM/MCAD recombinant protein

Recombinant Human ACADM/MCAD Protein (N-6His)

Cat. Num. AAA2552315

• Gene Names: ACADM; MCAD; ACAD1; MCADH
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: ACADM/MCAD; Recombinant Human ACADM/MCAD Protein (N-6His); Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochondrial; MCAD; ACADM; ACADM/MCAD recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM Tris, 0.1M NaCl, 20% Glycerol, pH 8.5.
• Sequence Positions: Lys26-Asn421
• Sequence Length: 421

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for ACADM/MCAD recombinant protein

Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death.

NCBI and Uniprot Product Information

• NCBI GI #: 4557231
• NCBI GeneID: 34
• NCBI Accession #: NP_000007.1
• NCBI GenBank Nucleotide #: NM_000016.5
• UniProt Accession #: P11310; Q5T4U4; Q9NYF1
• Molecular Weight: Molecular Mass: 45.9 kDa; Actual Protein Molecular Mass: 42 kDa
• NCBI Official Full Name: medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a
• NCBI Official Synonym Full Names: acyl-CoA dehydrogenase medium chain
• NCBI Official Symbol: ACADM
• NCBI Official Synonym Symbols: MCAD; ACAD1; MCADH
• NCBI Protein Information: medium-chain specific acyl-CoA dehydrogenase, mitochondrial
• UniProt Protein Name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
• UniProt Gene Name: ACADM
• UniProt Synonym Gene Names: MCAD

NCBI Description

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).