ATP-binding cassette sub-family G member 8 (Abcg8) Recombinant Protein | Abcg8 recombinant protein

Recombinant Rat ATP-binding cassette sub-family G member 8 (Abcg8)

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: ATP-binding cassette sub-family G member 8 (Abcg8); Recombinant Rat ATP-binding cassette sub-family G member 8 (Abcg8); Abcg8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-694
• Sequence: MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQGGTCLRSWGQEDPHMSLGLSESVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVPGDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW
• Sequence Length: 672

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Related Product Information for Abcg8 recombinant protein

Abcg8

NCBI and Uniprot Product Information

• NCBI GI #: 26080338
• NCBI GeneID: 155192
• NCBI Accession #: NP_569098.2
• NCBI GenBank Nucleotide #: NM_130414.2
• UniProt Accession #: P58428; Q8CIQ5; Q923R7
• Molecular Weight: 78,236 Da
• NCBI Official Full Name: ATP-binding cassette sub-family G member 8
• NCBI Official Synonym Full Names: ATP-binding cassette, subfamily G (WHITE), member 8
• NCBI Official Symbol: Abcg8
• NCBI Protein Information: ATP-binding cassette sub-family G member 8; sterolin 2; sterolin-2; ATP-binding cassette, sub-family G (WHITE), member 8
• UniProt Protein Name: ATP-binding cassette sub-family G member 8
• Protein Family: ABC transporter G family
• UniProt Gene Name: Abcg8
• UniProt Entry Name: ABCG8_RAT

NCBI Description

ATP-binding cassette (ABC) transporter that regulates sterol absorption and excretion; mutation causes sitosterolemia [RGD, Feb 2006]

Uniprot Description

Function: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Subunit structure: May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein

Probable.

Tissue specificity: Highest expression in liver, with lower levels in small intestine and colon. Ref.3

Sequence similarities: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]Contains 1 ABC transmembrane type-2 domain.Contains 1 ABC transporter domain.

Caution: Seems to have a defective ATP-binding region.