ATP-binding cassette sub-family D member 3 (Abcd3) Recombinant Protein | Abcd3 recombinant protein

Recombinant Rat ATP-binding cassette sub-family D member 3 (Abcd3)

• Gene Names: Abcd3; PMP70; Pxmp1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: ATP-binding cassette sub-family D member 3 (Abcd3); Recombinant Rat ATP-binding cassette sub-family D member 3 (Abcd3); Recombinant ATP-binding cassette sub-family D member 3 (Abcd3); ATP-binding cassette sub-family D member 3; 70 kDa peroxisomal membrane protein; PMP70; Abcd3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-659
• Sequence: AAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS
• Sequence Length: 659

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 6981450
• NCBI GeneID: 25270
• NCBI Accession #: NP_036936.1
• NCBI GenBank Nucleotide #: NM_012804.1
• UniProt Accession #: P16970
• Molecular Weight: 75,316 Da
• NCBI Official Full Name: ATP-binding cassette sub-family D member 3
• NCBI Official Synonym Full Names: ATP-binding cassette, subfamily D (ALD), member 3
• NCBI Official Symbol: Abcd3
• NCBI Official Synonym Symbols: PMP70; Pxmp1
• NCBI Protein Information: ATP-binding cassette sub-family D member 3; Peroxisomal membrane protein 1; 70 kDa peroxisomal membrane protein; 70-kDa peroxisomal membrane protein; ATP-binding cassette, sub-family D (ALD), member 3
• UniProt Protein Name: ATP-binding cassette sub-family D member 3
• Protein Family: ABC transporter D family
• UniProt Gene Name: Abcd3
• UniProt Synonym Gene Names: Pmp70; Pxmp1; PMP70
• UniProt Entry Name: ABCD3_RAT

NCBI Description

may form an ATP binding channel; may play a role in active transport in peroxisomes [RGD, Feb 2006]

Uniprot Description

ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes.

Protein type: Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: peroxisomal membrane; peroxisomal matrix; intracellular membrane-bound organelle; membrane; mitochondrion; mitochondrial inner membrane; integral to membrane; peroxisome

Molecular Function: protein binding; protein homodimerization activity; protein self-association; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; ATP binding

Biological Process: response to drug; fatty acid beta-oxidation; metabolic process; peroxisomal long-chain fatty acid import; peroxisome organization and biogenesis; very-long-chain fatty acid catabolic process; transmembrane transport; response to organic cyclic substance