Cavy Period Circadian Protein Homolog 3 (PER3) ELISA Kit | PER3 elisa kit
Cavy Period Circadian Protein Homolog 3 (PER3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Uniprot Description
PER3: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component: cytoplasm; nucleus
Molecular Function: kinase binding; protein binding; ubiquitin protein ligase binding
Biological Process: circadian regulation of gene expression; negative regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of circadian sleep/wake cycle, sleep; transcription, DNA-dependent
Disease: Advanced Sleep Phase Syndrome, Familial, 3
Research Articles on PER3
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Product Notes
The Cavy PER3 per3 (Catalog #AAA9909857) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9909857 ELISA Kit recognizes Cavy PER3. It is sometimes possible for the material contained within the vial of "Period Circadian Protein Homolog 3 (PER3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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