Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Aspartyl-tRNA synthetase, mitochondrial (DARS2) Standard Curve.)
Human Aspartyl-tRNA Synthetase, Mitochondrial (DARS2) ELISA Kit | DARS2 elisa kit
Human Aspartyl-tRNA Synthetase, Mitochondrial (DARS2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Aspartyl-tRNA synthetase, mitochondrial (DARS2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Aspartyl-tRNA synthetase, mitochondrial (DARS2) Standard Curve.)
Background: The protein encoded by DARS2 belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in DARS2 are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
Uniprot Description
DARS2: Defects in DARS2 are a cause of leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). LBSL is an autosomal recessive disease and is defined on the basis of a highly characteristic constellation of abnormalities observed by magnetic resonance imaging and spectroscopy. Affected individuals develop slowly progressive cerebellar ataxia, spasticity, and dorsal column dysfunction, sometimes with a mild cognitive deficit or decline. Belongs to the class-II aminoacyl-tRNA synthetase family.
Protein type: Ligase; Translation; EC 6.1.1.12; Mitochondrial
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; nucleus
Molecular Function: protein binding; protein homodimerization activity; aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; ATP binding; tRNA binding
Biological Process: tRNA aminoacylation for protein translation; gene expression; tRNA aminoacylation
Disease: Leukoencephalopathy With Brainstem And Spinal Cord Involvement And Lactate Elevation
Research Articles on DARS2
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Product Notes
The Human DARS2 dars2 (Catalog #AAA9715807) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715807 ELISA Kit recognizes Human DARS2. It is sometimes possible for the material contained within the vial of "Aspartyl-tRNA Synthetase, Mitochondrial (DARS2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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