Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Next to BRCA1 gene 1 protein (NBR1) Standard Curve.)
Human Next To BRCA1 Gene 1 Protein (NBR1) ELISA Kit | NBR1 elisa kit
Human Next To BRCA1 Gene 1 Protein (NBR1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Next to BRCA1 gene 1 protein (NBR1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Next to BRCA1 gene 1 protein (NBR1) Standard Curve.)
Background: Autophagy cargo receptor encoded by NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. Autophagy cargo receptor contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. NBR1 is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Description
NBR1: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: membrane; lysosome; late endosome; M band; autophagic vacuole; cytoplasmic vesicle; cytosol
Molecular Function: ubiquitin binding; protein binding; zinc ion binding; mitogen-activated protein kinase binding
Biological Process: regulation of stress-activated MAPK cascade; macroautophagy; negative regulation of osteoblast differentiation; regulation of bone mineralization; protein oligomerization
Research Articles on NBR1
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Product Notes
The Human NBR1 nbr1 (Catalog #AAA9715017) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715017 ELISA Kit recognizes Human NBR1. It is sometimes possible for the material contained within the vial of "Next To BRCA1 Gene 1 Protein (NBR1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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