Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Protocadherin gamma-A2 (PCDHGA2) Standard Curve.)
Human Protocadherin gamma-A2 (PCDHGA2) ELISA Kit | PCDHGA2 elisa kit
Human Protocadherin gamma-A2 (PCDHGA2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Protocadherin gamma-A2 (PCDHGA2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Protocadherin gamma-A2 (PCDHGA2) Standard Curve.)
Background: Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of nonclassic cadherins. PCDHGA2 is 1 of 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain. For further information on the PCDHG. By genomic sequence analysis, Wu et al. (2001) mapped the PCDHGA2 gene to 5q31, between the PCDHGA1 gene and the PCDHGA3 gene. They localized the mouse PCDHG genes to chromosome 18c.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Uniprot Description
PCDHGA2: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: integral to membrane; plasma membrane
Molecular Function: calcium ion binding
Biological Process: homophilic cell adhesion
Research Articles on PCDHGA2
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Product Notes
The Human PCDHGA2 pcdhga2 (Catalog #AAA9714960) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714960 ELISA Kit recognizes Human PCDHGA2. It is sometimes possible for the material contained within the vial of "Protocadherin gamma-A2 (PCDHGA2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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