Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Beta-2 adrenergic receptor (ADRB2) Standard Curve.)
Rat Beta-2 Adrenergic Receptor (ADRB2) ELISA Kit | ADRB2 elisa kit
Rat Beta-2 Adrenergic Receptor (ADRB2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Beta-2 adrenergic receptor (ADRB2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Beta-2 adrenergic receptor (ADRB2) Standard Curve.)
Background: ADRb2 is directly associated with one of its ultimate effectors, the class C L-type calcium channel CaV1.2. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
NCBI and Uniprot Product Information
NCBI Description
binds adrenergic receptor agonist zinterol; plays a role in G-protein coupled receptor regulation of calcium channel current [RGD, Feb 2006]
Uniprot Description
ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1
Cellular Component: apical plasma membrane; axon; caveola; cytoplasm; dendrite; dendritic spine; early endosome; endosome; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane; receptor complex; sarcolemma
Molecular Function: adenylate cyclase binding; B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; enzyme binding; epinephrine binding; G-protein alpha-subunit binding; ionotropic glutamate receptor binding; norepinephrine binding; PDZ domain binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity
Biological Process: adenylate cyclase activation; aging; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; associative learning; bone resorption; brown fat cell differentiation; diaphragm contraction; diet induced thermogenesis; female pregnancy; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; heat generation; liver development; negative regulation of angiogenesis; negative regulation of inflammatory response; negative regulation of multicellular organism growth; negative regulation of ossification; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of apoptosis; positive regulation of ATPase activity; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of MAPKKK cascade; positive regulation of potassium ion transport; positive regulation of protein ubiquitination; positive regulation of skeletal muscle growth; positive regulation of the force of heart contraction by epinephrine; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; receptor-mediated endocytosis; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; regulation of sodium ion transport; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; regulation of vasodilation; response to cold; response to estrogen stimulus; response to hypoxia; response to progesterone stimulus; response to testosterone stimulus; synaptic transmission, glutamatergic; wound healing
Research Articles on ADRB2
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Product Notes
The Rat ADRB2 adrb2 (Catalog #AAA9711976) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9711976 ELISA Kit recognizes Rat ADRB2. It is sometimes possible for the material contained within the vial of "Beta-2 Adrenergic Receptor (ADRB2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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