Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Reelin (RELN) Standard Curve.)
Rat Reelin (RELN) ELISA Kit | RELN elisa kit
Rat Reelin (RELN) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Reelin (RELN) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Reelin (RELN) Standard Curve.)
Background: Reelin is a protein that helps regulate processes of neuronal migration and positioning in the developing brain. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like subventricular and subgranular zones. It is found not only in the brain, but also in the spinal cord, blood, and other body organs and tissues. Reelin has been suggested to be implicated in pathogenesis of several brain diseases.
NCBI and Uniprot Product Information
NCBI Description
regulates neuronal cell migration during development; plays a role in locomotor behavior [RGD, Feb 2006]
Uniprot Description
reelin: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Defects in RELN are the cause of lissencephaly type 2 (LIS2); also known as lissencephaly with cerebellar hypoplasia or Norman-Roberts syndrome. LIS2 is a classic type lissencephaly associated with abnormalities of the cerebellum, hippocampus and brainstem. Individuals with LIS2 are severely ataxic, mentally retarded and suffer from epilepsy. Belongs to the reelin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Secreted, signal peptide; Secreted; Cell adhesion; EC 3.4.21.-; Protease; Motility/polarity/chemotaxis
Cellular Component: axon; cell soma; cytoplasm; dendrite; extracellular space; neuron projection; perikaryon; proteinaceous extracellular matrix
Molecular Function: metal ion binding; protein serine/threonine/tyrosine kinase activity; serine-type peptidase activity
Biological Process: activation of CREB transcription factor; associative learning; axon guidance; brain development; cell adhesion; cell migration; cellular morphogenesis during differentiation; central nervous system development; cerebral cortex development; cerebral cortex tangential migration; dendrite development; dentate gyrus development; forebrain development; glial cell differentiation; hippocampus development; hypothalamus development; layer formation in the cerebral cortex; learning; locomotory behavior; long-term memory; memory; midgut development; neuron migration; orbitofrontal cortex development; peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase activity; positive regulation of small GTPase mediated signal transduction; positive regulation of synaptic transmission, glutamatergic; positive regulation of TOR signaling pathway; proteolysis; regulation of behavior; regulation of gene expression; regulation of synaptic transmission; response to amino acid stimulus; response to axon injury; response to corticosterone stimulus; response to drug; response to electrical stimulus; response to ethanol; response to hormone stimulus; response to insecticide; response to lithium ion; response to mechanical stimulus; response to organic cyclic substance; response to pain; response to progesterone stimulus; response to toxin; social behavior; spinal cord patterning; thyroid hormone metabolic process; ventral spinal cord development
Research Articles on RELN
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Product Notes
The Rat RELN reln (Catalog #AAA9711927) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9711927 ELISA Kit recognizes Rat RELN. It is sometimes possible for the material contained within the vial of "Reelin (RELN), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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