Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) Recombinant Protein | Tnfrsf1a recombinant protein
Recombinant Mouse Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a)
NCBI and Uniprot Product Information
Uniprot Description
TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: Golgi apparatus; extracellular space; cell surface; protein complex; mitochondrion; integral to membrane; cytosol; lipid raft; Golgi membrane; membrane; axon; plasma membrane; synapse; intracellular; nucleus; receptor complex
Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding
Biological Process: positive regulation of protein import into nucleus, translocation; apoptosis; protein heterooligomerization; cytokine and chemokine mediated signaling pathway; programmed cell death; defense response; positive regulation of tumor necrosis factor production; signal transduction; prostaglandin metabolic process; regulation of apoptosis; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; positive regulation of neuron apoptosis; negative regulation of inflammatory response; defense response to bacterium; negative regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of inflammatory response; negative regulation of apoptosis
Research Articles on Tnfrsf1a
Similar Products
Product Notes
The Tnfrsf1a tnfrsf1a (Catalog #AAA965723) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-212. The amino acid sequence is listed below: IHPSGVTGL VPSLGDREKR DSLCPQGKYV HSKNNSICCT KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL SCKTCRKEMS QVEISPCQAD KDTVCGCKEN QFQRYLSETH FQCVDCSPCF NGTVTIPCKE TQNTVCNCHA GFFLRESECV PCSHCKKNEE CMKLCLPPPL ANVTNPQDSG TA. It is sometimes possible for the material contained within the vial of "Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
