Granulocyte colony-stimulating factor receptor Recombinant Protein | CSF3R recombinant protein

Recombinant Human Granulocyte colony-stimulating factor receptor

Cat. Num. AAA964629

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Granulocyte colony-stimulating factor receptor; Recombinant Human Granulocyte colony-stimulating factor receptor; Colony-stimulating factor; CSF; Molgramostin; Sargramostim; CSF3R recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 25-620aa; Extracellular Domain
• Sequence: ECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLT
• Sequence Length: 836

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for CSF3R recombinant protein

Cytokine that stimulates the growth and differentiation of hatopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Product Categories/Family for CSF3R recombinant protein

Cancer

References

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.Lee F., Yokota T., Otsuka T., Gemmell L., Larson N., Luh J., Arai K., Rennick D.Proc. Natl. Acad. Sci. U.S.A. 82:4360-4364(1985) Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.Kaushansky K., O'Hara P.J., Berkner K., Segal G.M., Hagen F.S., Adamson J.W.Proc. Natl. Acad. Sci. U.S.A. 83:3101-3105(1986) Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.Cantrell M.A., Anderson D., Cerretti D.P., Price V., McKereghan K., Tushinski R.J., Mochizuki D.Y., Larsen A., Grabstein S., Gillis S., Cosman D.Proc. Natl. Acad. Sci. U.S.A. 82:6250-6254(1985) Human GM-CSF molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.Wong G.G., Witek J.S., Temple P.A., Wilkens K.M., Leary A.C., Luxenberg D.P., Jones S.S., Brown E.L., Kay R.M., Orr E.C., Shoemaker C., Golde D.W., Kaufman R.J., Hewick R.M., Wang E.A., Clark S.C.Science 228:810-815(1985) Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor comparison of the mouse and human genes.Miyatake S., Otsuka T., Yokota T., Lee F., Arai K.EMBO J. 4:2561-2568(1985) SeattleSNPs variation discovery resourceThe DNA sequence and comparative analysis of human chromosome 5.Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.Nature 431:268-274(2004) Bhattacharya P., Pandey G., Mukherjee K.J. Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells.Kaushansky K., Lopez J.A., Brown C.B.Biochemistry 31:1881-1886(1992) Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.Diederichs K., Boone T., Karplus P.A.Science 254:1779-1782(1991) Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.Walter M.R., Cook W.J., Ealick S.E., Nagabhushan T.L., Trotta P.P., Bugg C.E.J. Mol. Biol. 224:1075-1085(1992) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.Hansen G., Hercus T.R., McClure B.J., Stomski F.C., Dottore M., Powell J., Ramshaw H., Woodcock J.M., Xu Y., Guthridge M., McKinstry W.J., Lopez A.F., Parker M.W.Cell 134:496-507(2008)

NCBI and Uniprot Product Information

• NCBI GI #: 4503081
• NCBI GeneID: 1441
• NCBI Accession #: NP_000751.1
• NCBI GenBank Nucleotide #: NM_000760.3
• UniProt Accession #: Q99062
• Molecular Weight: 93.5 kDa
• NCBI Official Full Name: granulocyte colony-stimulating factor receptor isoform a
• NCBI Official Synonym Full Names: colony stimulating factor 3 receptor
• NCBI Official Symbol: CSF3R
• UniProt Protein Name: Granulocyte colony-stimulating factor receptor
• Protein Family: Granulocyte colony-stimulating factor receptor
• UniProt Gene Name: CSF3R
• UniProt Synonym Gene Names: GCSFR; G-CSF receptor; G-CSF-R
• UniProt Entry Name: CSF3R_HUMAN

NCBI Description

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

Uniprot Description

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: extracellular region; integral to plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity

Biological Process: cell adhesion; cytokine and chemokine mediated signaling pathway; defense response; neutrophil chemotaxis; regulation of myeloid cell differentiation; signal transduction

Disease: Neutrophilia, Hereditary