Macrophage mannose receptor 1 (MRC1) Recombinant Protein | MRC1 recombinant protein

Recombinant Human Macrophage mannose receptor 1 (MRC1), partial

Cat. Num. AAA963867

• Gene Names: MRC1; MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Macrophage mannose receptor 1 (MRC1); Recombinant Human Macrophage mannose receptor 1 (MRC1); partial; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD206; MRC1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 655-1213aa, Partial
• Sequence: RTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCK

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for MRC1 recombinant protein

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Product Categories/Family for MRC1 recombinant protein

Immunology

References

Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains.Taylor M.E., Conary J.T., Lennartz M.R., Stahl P.D., Drickamer K.J. Biol. Chem. 265:12156-12162(1990) Molecular characterization of the human macrophage mannose receptor demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.Ezekowitz R.A., Sastry K., Bailly P., Warner A.J. Exp. Med. 172:1785-1794(1990) Organization of the gene encoding the human macrophage mannose receptor (MRC1) .Kim S.J., Ruiz N., Bezouska K., Drickamer K.Genomics 14:721-727(1992) NHLBI resequencing and genotyping service (RS&G) The DNA sequence and comparative analysis of human chromosome 10.Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.Nature 429:375-381(2004) Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor.Taylor M.E., Bezouska K., Drickamer K.J. Biol. Chem. 267:1719-1726(1992) Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.Proteomics 8:3833-3847(2008) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor.Feinberg H., Park-Snyder S., Kolatkar A.R., Heise C.T., Taylor M.E., Weis W.I.J. Biol. Chem. 275:21539-21548(2000) Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility.Alter A., de Leseleuc L., Van Thuc N., Thai V.H., Huong N.T., Ba N.N., Cardoso C.C., Grant A.V., Abel L., Moraes M.O., Alcais A., Schurr E.Hum. Genet. 127:337-348(2010)

NCBI and Uniprot Product Information

• NCBI GI #: 4505245
• NCBI GeneID: 4360
• NCBI Accession #: NP_002429.1
• NCBI GenBank Nucleotide #: NM_002438.3
• UniProt Accession #: P22897; Q5VSJ2; Q5VSK2; A5PKW3
• Molecular Weight: 66.4 kDa
• NCBI Official Full Name: macrophage mannose receptor 1
• NCBI Official Synonym Full Names: mannose receptor, C type 1
• NCBI Official Symbol: MRC1
• NCBI Official Synonym Symbols: MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
• NCBI Protein Information: macrophage mannose receptor 1
• UniProt Protein Name: Macrophage mannose receptor 1
• Protein Family: Macrophage mannose receptor
• UniProt Gene Name: MRC1
• UniProt Synonym Gene Names: CLEC13D; CLEC13DL; MRC1L1; MMR; hMR
• UniProt Entry Name: MRC1_HUMAN

NCBI Description

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

Uniprot Description

MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: cell surface; endosome membrane; integral to plasma membrane; plasma membrane

Molecular Function: mannose binding; protein binding; receptor activity; transmembrane receptor activity; viral receptor activity

Biological Process: entry of virus into host cell; receptor-mediated endocytosis; signal transduction